BRCA1 and BRCA2 Gene Mutations

Testing for BRCA1 and BRCA2 Gene Mutations BRCA Gene Mutations and Hereditary Cancer Risk Breast cancer is the most common type of cancer in women after skin cancer; in the general population, 1 in 8 women (about 13%) will develop breast cancer in their lifetime. While many factors may increase the risk of cancer, such […]

CancerSeq: A Next Generation of FFPE tissues

Next Generation Sequencing (NGS) The revolution in the NGS technology over the last decade has greatly enhanced our understanding of genomes. NGS is finding increasing application in cancer genomics research for biomarker discovery, tumor stratification and precision medicine. It provides high speed and throughput as thousands of DNA molecules can be sequenced in parallel generating […]

NGS Webinar

On-Demand Webinar Topic: Gene-Characterized FFPE Tissues for Validation and Discovery on June 9th Register for it and we’ll send you the recorded talk! This webinar will be pre-recorded for our international customers. A Youtube link will be emailed to you on June 9th to view the webinar. Keep an eye out for it! Please send […]

Storing RNA at Room Temperature

A Reliable and Smart Laboratory Cost Cutting Approach Author: Franklin Chin Featured Products BioChain offers various RNA samples from human taken from: Bone Marrow Brain Breast Cell-Line Colon Heart Liver Lung Pancreas To read the full application – note, please fill out this form!

Importance of Circulating Cell-free Tumor DNA (ctDNA) in Liquid Biopsies for Cancer Prognosis

Liquid biopsies offer a minimally invasive method for effective cancer detection and prognosis in the form of circulating biomarkers (Cree 2015). Though the exclusivity and conclusivity of liquid biopsies as the most efficacious forms of cancer prognosis and treatment remains doubtful, there is no second thought to admitting its importance in the identification of therapeutically […]

Circulating Tumor DNA (ctDNA) can Diagnose, Treat, and Monitor Cancer

What is Circulating Tumor DNA? Deoxyribonucleic acid is a collection of nucleotides that carry genetic information necessary for the functioning of all living beings. DNA is primarily found in the nucleus of cells. When strands of DNA are found circulating in the body without a cell, it is referred to as cell free DNA (cfDNA). […]

A Tale of Two Biopsies: Liquid Biopsy vs Tissue Biopsy

Liquid biopsy is the innovative solution to cancer detection and treatment. While liquid biopsies are revolutionizing oncology, they are not yet ready to entirely replace their competition, solid tissue biopsies. This article examines the differences between the two forms of biopsy, and how both must be used together for the most effective outcomes. Comparison of […]

RNAscope ISH

Advanced RNA-ISH for Detection of RNA in FFPE Tissues Written by: Rikita Gakhar Fill out this form to download the Application Note!

BioChain’s vamPure kit can facilitate your COVID-19 research

BioChain’s vamPure kit can facilitate your COVID-19 research Introduction The current pandemic of COVID-19 caused by SARS-CoV-2 virus has challenged the governments and healthcare systems worldwide with unprecedented social and economic distress. As of 3rd January 2021, 85.4M individuals have been infected worldwide and 1.8M deaths have been reported. While it caused individuals to isolate, […]

Application of a Highly Sensitive Method for Early Detection of Cancer

Application of a Highly Sensitive Method for Early Detection of Cancer This application note describes the use of matched biological tissue and plasma sample sets to detect predictive biomarkers in colorectal cancer. Using DNA extracted from these samples in conjunction with a special next-generation sequencing (NGS) technology, the common KRAS G12D and BRAF V600E variants […]

Cancer Detection using BioChain’s cfPure kit

Groundbreaking Cancer detection study has its foundations in BioChain technology There have been tremendous advances in cancer treatment since President Richard Nixon declared war on malignancies in 1971. Despite having treatments such as targeted radiation, estrogen blockers, and CAR-T cell immunotherapies, early detection of cancer remains one of the most important factors. For instance, the […]

BioChain Introduces New Lines of HPV and Microsatellite instability (MSI) Characterized FFPE Tissue Products

BioChain Introduces New Lines of HPV and Microsatellite instability (MSI) Characterized FFPE Tissue Products To expand its characterized tissue product line, BioChain proudly introduces HPV Characterized and MSI Characterized FFPE tissue products. FFPE HPV Characterized HPV infection has been reported to correlate with several cancer types, especially squamous cell carcinomas originating from head and neck […]

Pros and Cons of using FFPE vs Cell-free DNA in NGS applications

Pros and Cons of using FFPE vs Cell-free DNA in NGS applications by Sujata Dhar Introduction to biopsy It is a surgical procedure to determine the presence of cancerous cells in our body. Tissue and liquid biopsy Tissue biopsy involves taking out a piece of tissue, examining it under a microscope and then making decision […]

Cancer Biomarkers: Methods for Detection and Applications in the Clinic

by Eric Torres  A biomarker is any biological signal that can be used to inform clinicians about a particular disease You’ve probably heard the term “biomarker” at some point while exploring current trends in cancer treatment. But what does the term really mean? The World Health Organization (WHO) has defined a biomarker as “any substance, […]

From Sanger to Next Generation Sequencing

From Sanger to Next Generation Sequencing Sujata Dhar Next generation sequencing (NGS) technology has opened a wealth of data and vital information in diverse areas of biological science. This includes knowing our history or ancestry, predisposition to a disease, microorganisms causing epidemics, risks involved in prenatal and newborn screening and other applications in personalized medicine. […]

The Basics of Tumor Grading and Cancer Staging

The Basics of Tumor Grading and Cancer Staging by Eric Torres Cancer is one of the most significant diseases worldwide. In 2018, over 1.7 million people were diagnosed with cancer in the United states. Moreover, approximately 38.4% of men and women are expected to be diagnosed with cancer in their lifetime (National Cancer institute). A […]

American Society of Human Genetics 2019 Annual Meeting

American Society of Human Genetics (ASHG) 2019 Annual Meeting Booth# 1608 George R. Brown Convention Center Houston, TX October 16-18 Join BioChain Institute Inc. at the ASHG 2019 taking place at the George R. Brown Convention Center in Houston, Texas. The American Society of Human Genetics Annual Meeting is held each fall in a major […]

The enzyme which made its mark in molecular biology

The enzyme which made its mark in molecular biology by Sujata Dhar Reverse Transcription: Its Discovery, Function, and Existence Reverse transcription is the process of generating cDNA (complementary DNA) from mRNA and the enzyme catalyzing this process is called reverse transcriptase (RT). It was during the 1970s that two scientists named Temin and Baltimore discovered […]

ISHI Annual Meeting 2019

ISHI (International Symposium on Human Identification) Booth # 115 Palm Springs Convention Center Palm Springs, CA September 23-26, 2019 Join BioChain Institute Inc. at the ISHI 2019 taking place at the Palm Springs Convention Center in Palm Springs, California. The ISHI is the largest annual meeting focusing entirely on DNA forensics. Discover the newest advances […]

Comparison of three commercially available circulating cell-free DNA (ccfDNA) extraction methods through low coverage whole genome sequencing.

Comparison of three commercially available circulating cell-free DNA (ccfDNA) extraction methods through low coverage whole genome sequencing. Geoffrey Routh, Ph.D. Introduction Since the late 1990s, circulating cell-free DNA (ccfDNA) has become an increasingly important and well-studied biomarker for cancer diagnostics (1), transplantation rejection (2), prenatal diagnosis (3) and other medically important biological processes. While diagnostic […]

ASCO Annual Meeting 2019

May 31- June 4, 2019 McCormick Place Chicago, Illinois Join BioChain Institute Inc. at the ASCO Annual Meeting 2019 taking place at the McCormick Place in Chicago, Illinois. The ASCO Annual Meeting is considered the world’s premier oncology conference, organized by the American Society of Clinical Oncology. Every year, the ASCO conference brings together more […]

BioChain Responds to Epigenomics’ unilateral termination of license contract

March 12, 2019 Newark, CA BioChain, a US-based company, said today Epigenomics AG of Germany seriously violated the terms of an ongoing licensing contract by publicly announcing on March 6, 2019 the unilateral termination of BioChain’s licensing right of Septin9 marker in China. The termination of the contract by Epigenomics is not legally effective. BioChain’s […]

Tips for Researchers Seeking to Purchase Reliable FFPE Samples

Tips for Researchers Seeking to Purchase Reliable FFPE Samples There currently exists no standard procedure or protocol to be used in the collection and fixation of the tissues. Consequently, differences in handling, fixation, and embedding of specimens has resulted in a wide variation of tissue sample quality. Even though finding reliable and high-quality FFPE samples can […]

Using dNTP in Polymerase Chain Reaction (PCR)

Polymerase Chain Reaction (PCR) is a technique that uses DNA polymerase to amplify a single strand or segment of DNA. With the final product ranging from thousands to millions of DNA copies, PCR is an extremely important part of medical and clinical research. The developers, Kary Mullis and Michael Smith, won a Nobel Prize in […]

Challenges in ctDNA Testing

Circulating tumor DNA (ctDNA) originates from tumor cells. It is a part of cell-free DNA that is distinguishable by characteristics present in the parent tumor, such as methylation mutations, copy number variations, and presence of specific biomarkers. Increasingly, ctDNA has been used in liquid biopsies to diagnose, treat, and monitor cancer. Find more details on […]

Protein Extraction Methods

A protein is a macromolecule that consists of a chain of amino acid residues that complete vital functions in the body. Ranging from DNA replication to catalyzing chemical reactions to providing structural support, proteins complete infinite tasks in the body essential for survival of the organism. Proteins are often classified by their structure, which takes […]

Challenges in ctDNA Testing

Circulating tumor DNA (ctDNA) originates from tumor cells. It is a part of cell-free DNA that is distinguishable by characteristics present in the parent tumor, such as methylation mutations, copy number variations, and presence of specific biomarkers. Increasingly, ctDNA has been used in liquid biopsies to diagnose, treat, and monitor cancer. Find more details on […]

UCSD Research Supplier Product Show

Join our product specialist Sandy Mavi from BioChain Institute Inc. at the Research Supplier Product Show taking place at the University of California San Diego . Find out what BioChain’s products have to offer in the way of tissues, DNA and RNA sequencing, PCR and RT-PCR, liquid biopsy kit, gene expression analysis, DNA and RNA […]

Types of RNA and How to Extract or Purchase It

While DNA is one of the basic elements in the cell and is commonly used in research, RNA is becoming increasingly collected and used in research. What is RNA? RNA (Ribonucleic acid) is found in the nucleus and is the result of the transcription of DNA (deoxyribonucleic acid) to RNA, which is then synthesized into […]

The Tissue Microarray: Tissue Analysis from Research to Treatment

A tissue microarray (TMA) is an innovative technique that can be used to analyze multiple tissue samples simultaneously. This cost-effective method has been used extensively across mediums in diagnosis, treatment, and research, proving its efficiency and versatility. History and Methodology of Creating a Tissue Microarray A tissue microarray arranges tiny amounts of biological matter preserved […]

Liquid Biopsies for the Early Detection of Lung Cancer

The Fight Against Lung Cancer Developments in liquid biopsies provide significant implications in the advancement of care for patients with lung cancer. Lung cancer currently stands as the leading cause of cancer mortality with annual deaths exceeding those of breast, prostate, and colon cancers combined. Yet, most cases are not diagnosed until the disease progresses […]

Liquid Biopsy: Revolutionizing Cancer Diagnoses and Treatments

Cancer has long remained a major cause of death in the United States. Billions of dollars are being spent every year in trying to find a cure which has eluded researchers for decades. The field of liquid biopsy may be the missing link for effective diagnosis and treatment methods, going a long way to finding […]

AACR Annual Meeting 2018

April 15-18, 2018 McCormick Place North/South Chicago, Illinois Join BioChain Institute Inc. at the AACR Annual Meeting 2018 taking place at the McCormick Place North/South in Chicago, Illinois. The AACR Annual Meeting highlights the best cancer science and medicine from institutions all over the world. Attendees are invited to stretch their boundaries, form collaborations, attend sessions […]

Cleveland Clinic Foundation Research Supplier Product Show

APR 12, 2018 Cleveland Clinic FoundationLerner Research Institute, Garden Hallway9620 Carnegie AvenueCleveland, Ohio 44195Join BioChain Institute Inc. at the Cleveland Clinic Foundation Research Supplier Product Show taking place at the Lerner Research Institute, Garden Hallway. Visit our booth at this popular LSE Event at the Cleveland Clinic Lerner Research Institute and meet with Vidyodhaya Sundaram Ph.D, MBA an alumni from […]

Alternative Methods of Detecting Gene Expression

Understanding gene expression in cells is a vital process. Its uses involve detecting diseases such as cancer and Hodgkins, identifying cell death and reproduction, and profiling the distribution of proteins in a cell. There are various methods involved in immunostaining frozen tissue. One of the most widely used of these methods is immunoflourescent staining, which […]

FFPE Tissue Preparation Steps

Formalin Fixed Paraffin Embedded tissue samples, or FFPE tissue samples, are biopsied human tissue that are prepared for preservation and are exceptionally useful resources for studying, analyzing, and diagnosing various diseases, as well as aiding in the process of gene expression profiling. In order to convert tissue samples into FFPE tissue samples, a specific procedure […]

The Process of Extracting RNA from Frozen Tissue

Ribonucleic acid (RNA) is vital to life, being present everywhere – from carrying genetic information to the production of deoxyribonucleic acid (DNA). However, RNA is one of the most fragile and delicate samples to extract and must be handled with care due to the presence of ribonuclease enzumes (RNases) which quickly degrade the RNA upon […]

Liquid Biopsy and Cancer Detection

Detecting cancer in its early stages can help give doctors and patients options for treatments plans. Tissue biopsies involve physically extracting and analyzing parts of suspicious lumps or tissues to determine if they are cancerous. Since this technique involves tools like large needles, endoscopes, and/or open surgery, if patients are unable to undergo these invasive measures, […]

Steps Involved in Genomic DNA Extraction

Genomic DNA, or gDNA, is the chromosomal DNA that encodes the genome of the organism, which includes all the biological information that is transferred to the next generation. It is very large and includes both coding and noncoding regions. In order to study this, or use it in other applications, it must first be extracted […]

The Polymerase Chain Reaction – What it is and How it Works

Polymerase chain reaction (PCR) is a technique used to amplify a known focused segment of genomic DNA, RNA, or plasmid DNA to generate millions of copies of DNA/RNA segments that have multiple uses in the fields of molecular biology and other related fields.  Genomic DNA is chromosomal DNA in organisms; in contrast, plasmids are circular […]

Detecting Viruses: ELISA and HPV

Enzyme-linked immunosorbent assay (ELISA) is a biochemical technique used in immunology to identify substances that portray antigenic properties that are present in a test subject’s bodily fluids. ELISA detects proteins instead of other small molecules, like glucose and potassium. This safe and easily reproduced technique has revolutionized the way people screen for viruses including the […]

cDNA vs Genomic DNA

The Relationship and Differences in Genomic DNA and Complimentary DNA DNA: the Building Block of Life Deoxyribonucleic acid, (DNA) is the molecule that carries the instructions for all aspects of an organism’s functions, from growth, to metabolism, to reproduction. In living organisms, most of the DNA resides in tightly coiled structures called chromosomes, located inside […]

Tips for Successful In Situ Hybridization

ISH (in situ hybridization) is a technique used for detecting specific DNA and RNA sequences in a tissue sample by using a labeled RNA or DNA probe.  The labeled probe is detected using an antibody. It is an important method used for scientific research in clinical settings.  It is also used as a diagnostic tool […]

FFPE DNA Damage and Extraction

FFPE DNA Damage Formalin-fixed paraffin-embedded (FFPE) tissues are a very common source of archived tissue samples that have been used by pathologists for decades. It allows for a long-term, room temperature storage solution for tissue samples, making it very convenient. Having been the standard for such a long time, it is also the predominant source of […]

ELISA Test Procedures

The enzyme linked immunosorbent assay (ELISA) is a highly sensitive test that detects and measures antibodies, neurobiological analytes, cytokines and phosphorylated proteins in blood which are molecules of interest in research labs. Applications For ELISA  This test is used as a screening tool and is used to determine the presence of antibodies for certain disease […]

Why to Utilize PCR Purification

Polymerase Chain Reaction, or PCR is a technique used to amplify DNA. It was first developed in 1983 by Kary Mullis who received the Nobel Prize in Chemistry in 1993 for his work. PCR is now a very common, cost-effective way of replicating DNA. PCR is accomplished using a DNA polymerase and two DNA primers, […]

Visit Us At Midwest Association of Core Directors

We will be showcasing our products cfPure and AnaPrep. Come visit us for more details. Midwest Association of Core Directors Dates:  October 11th-13th Crowne Plaza – Chicago West Loop Chicago, IL

Isolation of Mitochondria from Cells and Tissues

As mitochondria are key to cellular health, it shouldn’t be surprising that an increasing number of human diseases are being traced back to these organelles.  This fact leads to an intensifying need for an effective method to isolate intact mitochondria from tissues and cultured cells. Introduction to Mitochondria: The mitochondrion’s primary function is to provide […]

Learn about DNA extraction from FFPE tissue in 10 minutes

Are you a histologist looking to learn of an exciting new use for formalin fixed, paraffin embedded (FFPE) tissue blocks and sections? If so, then you are in the right place. DNA analyses such as next generation sequencing (NGS), PCR-based diagnostics, and microarray are all possible on nucleic acids extracted from this sample type. Tissues […]

Using NGS panels to sequence FFPE cancer tumor tissue 

Next generation DNA sequencing (AKA next gen sequencing, or NGS) is an enormously powerful tool for cancer research, with numerous companies such as Illumina, ArcherDx, Pillar BioSciences, and Accuragen developing specific kits to identify DNA mutations in specific regions, known as cancer hotspots, in the human genome.  These NGS cancer gene panels can be used […]

Cell-Free DNA and Cancer

According to the National Cancer Institute, cancer is among the leading causes of death worldwide. Worldwide cancer cases are expected to double by fifty percent from 2012 to 2030.   The Cancer Moon Shoot is a project funded by NCI to advance and accelerate cancer research and make cure and therapies available for patients across the […]

Cell Free DNA & Prenatal Testing

One of the most promising new developments in modern medicine has been the discovery of cell-free DNA (cfDNA). CfDNA is released into the bloodstream or other body fluids when cells die due to apoptosis and necrosis. Two fields where cfDNA has already led to improvements are prenatal testing and oncology. Noninvasive prenatal testing (NIPT): Cell- […]

What Is FFPE Tissue And What Are Its Uses

The Versatility and Necessity of Formalin-Fixed Paraffin-Embedded Tissue Methodology: Preparation and Storage Formalin-Fixed Paraffin-Embedded (FFPE) tissue specimens have been a staple of research and therapeutic applications for decades. FFPE is a form of preservation and preparation for biopsy specimens that aids in examination, experimental research, and diagnostic/drug development. A tissue sample is first preserved by […]

Nucleic Acid Extraction Methods 

Nucleic acid extraction methods are key to molecular biology, and are routinely utilized in many applications in both medical and biological sciences.  Nucleic acids were first extracted in 1869 by Friedrich Miescher, when he was studying the chemical nature of the nuclei of white blood cells.  In 1953, Rosalind Franklin, James Watson, and Francis Crick […]

FFPE vs Frozen Tissue Samples 

FFPE vs frozen tissue will be explored in this article. Medical research on cancer and other diseases requires access to unique tools and materials – including specimens to study.  For instance, if you are examining cell shape and structure (morphology), disease states, intra- and inter cellular communication, or related topics, it is incredibly useful to have […]

Visit Us At AACC 2017 Annual Meeting! – Booth #551

1We will be showcasing our newest product cfPure™ at AACC this year. Come visit us for more details. Location: San Diego Convention Center, San Diego, CA Exhibit Dates: July 30 – August 3, 2017 Booth: #551

Visit Us At AACR 2017 Annual Meeting!

We will be showcasing our newest product cfPure™ at AACR this year. Come visit us for more details. Location: Walter E. Washington Convention Center, Washington, DC. Exhibit Dates: April 2 – 5th, 2017 Booth: #3238

BioChain and Mawi DNA Technologies collaborate on poster at AASF

BioChain and Mawi DNA Technologies collaborated on a poster at AASF using AnaPrep Automated Nucleic Acid Extraction System with iSWAB.  DNA was efficiently extracted using AnaPrep from swab samples stored in iSWAB liquid-based sample collection system.  The isolated DNA were successfully used for STR profiling.

BioChain and Epigenomics AG Enter Strategic License Agreement

BioChain announced that it has entered a strategic license agreement with Epigenomics AG (Frankfurt Prime Standard: ECX, OTCQX: EPGNY), a German-American cancer molecular diagnostic company, on the development and commercialization of a novel, blood-based lung cancer test for China. BioChain will initiate a clinical trial to validate the lung cancer detection test with the goal […]

BioChain and ArcherDX to Provide NGS-characterized FFPE Tumor Samples

BioChain is proud to launch CancerSeq™ Plus. This next generation sequence (NGS) characterized FFPE tumor tissues is the product of a non-exclusive agreement with ArcherDX. Multiple types of tumor FFPE samples, including NSCLC samples, will be comprehensively screened for oncogenic fusions, copy number variations (CNVs), single nucleotide variants (SNVs) and insertions/deletions (indels) using the Archer […]

BioChain Launches Newly Released SeqPure PCR Purification System

BioChain is proud to announce our newly released SeqPure PCR Purification System – which utilizes magnetic bead technology to remove contaminants from DNA. SeqPure efficiently and selectively binds DNA fragments that are 100 bp or larger in size, while removing salts, primers, dNTPs, nucleotides, enzymes, and residual proteins, resulting in a purified product suitable for […]

BioChain and Epigenomics announce inclusion of blood-based Septin9 test in Chinese Screening Guideline for colorectal cancer

BioChain, an early cancer diagnostic company in China, and its strategic commercialization partner, Epigenomics AG, a German- announced that testing based on the proprietary Septin9 biomarker was included in the Chinese guideline on screening, endoscopic diagnosis and treatment of early colorectal cancer (CRC). The guideline, recently officially published in the Chinese Journal of Digestive Endoscopy, […]

Epigenomics and BioChain Announce Approval of Epi proColon® in China

Berlin (Germany), Germantown, MD, and Newark, CA (U.S.A.) and Beijing (China), December 08, 2014 – Epigenomics AG (Frankfurt Prime Standard: ECX, OTCQX: EPGNY), the German-American cancer molecular diagnostics company, and BioChain, a leading clinical diagnostics company in cancer and genetic testing in China and the U.S.A., announced today that the China Food and Drug Administration […]

BioChain Strengthens Alliance with Epigenomic in Subscribing 1.35 Million Shares of Stock

Newark, CA (U.S.A.), Beijing (China) and Berlin (Germany), Germantown, MD (U.S.A) – BioChain, a leading clinical diagnostics company in cancer and genetic tests in China and the US, and Epigenomics AG (Frankfurt Prime Standard: ECX, OTC: EPGNY), the German-American cancer molecular diagnostics company, announced that the Epigenomic is raising USD 5.3 million (EUR 4.2 million) […]

BioChain Announces Colorectal Screening Deal with Clinical Genomics

Newark, CA (U.S.A.)- BioChain, a leading clinical diagnostics company in cancer and genetic testing with operations in USA and China and Clinical Genomics, an Australian biotechnology company have announced a deal that makes BioChain the exclusive distributor of Clinical Genomics’ colorectal cancer screening technology throughout China. This deal comes at a time when China’s cancer […]

BioChain is Proud to Announce ISO 9001:2008 and ISO 13485:2003 Recertification

At BioChain we are committed to delivering exceptional products to our customers. Our production undergoes rigorous Quality Control and Quality Management to provide consistent quality products. The international criteria and standardization of quality management is set forth by ISO 9001:2008; however, this certification is not a mandatory requirement for all organizations. BioChain has pursued this […]