Application of a Highly Sensitive Method for Early Detection of Cancer

This application note describes the use of matched biological tissue and plasma sample sets to detect predictive biomarkers in colorectal cancer. Using DNA extracted from these samples in conjunction with a special next-generation sequencing (NGS) technology, the common KRAS G12D and BRAF V600E variants were detected in patients with stage 1 colorectal cancer.

Authors: Franklin Chin, Vidyodhaya Sundaram, Vinh Lam and Zhongdong Lui

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Primary and Matched Pair Samples

Consists of FFPE tissue sections of the primary tumor and corresponding metastatic tumor from the same donor

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FFPE tumor tissues prescreened for SNPs, Indels, CNVs. NGS Characterized using Cancer gene panels to identify mutations and mutational hot spots

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Cell-Free DNA Extraction Kit designed for rapid & efficient purification of circulating cfDNA 

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