Two-Dimensional N-Glycan Distribution Mapping of Hepatocellular Carcinoma Tissues by MALDI-Imaging Mass Spectrometry

Thomas W. Powers, Stephanie Holst, Manfred Wuhrer, Anand S. Mehta, Richard R. Drake
Biomolecules Oct 15, 2015
Tissue sections used in this study were de-identified and obtained commercially from Biochain (Newark, CA, USA). These include a slide with two FFPE tissue sections from a 60 year old female with a poorly differentiated hepatocellular carcinoma; patient matched tumor and normal FFPE tissue sections from a 53 year old male with hepatocellular carcinoma, and a patient matched renal cell carcinoma tumor and lymph node tissue with renal cell carcinoma metastasis from a 28 year old female. A subset of a commercially available renal tissue microarray (TMA) from Biochain was also analyzed. “FFPE tissue sections not acquired precut from Biochain, were sectioned at 5 µm and mounted on positively charged slides compatible with the Bruker slide adaptor.” “An HCC TMA slide (Catalog No.: Z7020059, Lot No.: B506168) was purchased from Biochain, Inc.”

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