P1 and P2′ site mutations convert protease nexin-2 from a factor XIa inhibitor to a plasmin inhibitor

Duraiswamy Navaneetham, Wenman Wu, Hongbo Li, Dipali Sinha, Ronald F Tuma, Peter N Walsh
J. Biochem. Feb 28, 2013
… and other sites, inserting the codon preferentially used in yeast, in the PN2KPI domain, such as PN2KPI-R 15 K, M 17 K, M 17 R and F 34 A, and double mutants R 15 KM 17 K and R 15 KM 17 R. As a PCR amplification product from bovine liver cDNA (BioChain Institute, Inc

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