Nucleoside Reverse Transcriptase Inhibitors Induce a Mitophagy-Associated Endothelial Cytotoxicity That Is Reversed by Coenzyme Q10 Cotreatment

Stephen Y Xue, Valeria Y Hebert, Danicia M Hayes, Corie N Robinson, Mitzi Glover, Tammy R Dugas
Toxicol. Sci. Jun 4, 2013
… Using a kit purchased from BioChain (Hayward, CA), complex IV activity was determined by monitoring the decrease in absorbance at 550nm produced by the cytochrome c oxidase-mediated oxidation of ferrocytochrome c to ferricytochrome c. …

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