In vitro and in vivo pharmacological profile of PL-3994, a novel cyclic peptide (Hept-cyclo(Cys-His-Phe-d-Ala-Gly-Arg-d-Nle-Asp-Arg-Ile-Ser-Cys)-Tyr-[Arg mimetic]-NH(2)) natriuretic peptide receptor-A agonist that is resistant to neutral endopeptidase and acts as a bronchodilator

Jeffrey D Edelson, Marie Makhlina, Kevin R Silvester, Shailesh S Vengurlekar, Xiaomei Chen, Jie Zhang, Cynthia J Koziol-White, Philip R Cooper, Trevor J Hallam, Douglas W P Hay, Reynold A Panettieri
Pulm Pharmacol Ther Apr 25, 2013
… constructed into a pcDNA3.1 (+) vector. 2.1.1.2 Dog NPR-A cloning and construction. Dog natriuretic peptide receptor-A (NPR-A) was cloned from dog testis cDNA (BioChain, Hayward, CA). Based on the sequences homologies …

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