Evaluation of Cynomolgus Monkey Pregnane X Receptor, Primary Hepatocyte, and in Vivo Pharmacokinetic Changes in Predicting Human CYP3A4 Induction

Sean Kim, Joseph E. Dinchuk, Monique N. Anthony, Tami Orcutt, Mary E. Zoeckler, Mary B. Sauer, Kathleen W. Mosure, Ragini Vuppugalla, James E. Grace, Jr., Jean Simmermacher, Heidi A. Dulac, Jennifer Pizzano, Michael Sinz
Drug Metab. Dispos. Jan 1, 2010
… …hyperforin or 0.87 mg/capsule. Molecular Cloning of cynoPXR. A cynomolgus monkey liver cDNA panel was purchased from the Biochain Institute (Hayward, CA). Forward (nucleotide 1-27) and reverse (1274-1305) primers were selected based on a rhesus monkey PXR… …

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