Application of a Highly Sensitive Method for Early Detection of Cancer

This application note describes the use of matched biological tissue and plasma sample sets to detect predictive biomarkers in colorectal cancer. Using DNA extracted from these samples in conjunction with a special next-generation sequencing (NGS) technology, the common KRAS G12D and BRAF V600E variants were detected in patients with stage 1 colorectal cancer.

Authors: Franklin Chin, Vidyodhaya Sundaram, Vinh Lam and Zhongdong Lui

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