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BioChain has developed a series of ELISA assays for the detection of infectious diseases, such as hepatitis, (HCV, HEV), HIV, TORCH, TB, etc. Our kits are for research use only in the United States while we have obtained regulatory approval for clinical use in other countries, such as China. These ELISA kits are enzyme immunoassays for the detection of various antigen or antibody in human serum or plasma. Either recombinant or purified antigen or antibody is coated on the multiple wells. When the serum sample and HRP conjugated second antibody are added to the coated wells, and if the target antibody or antigen is present in the sample, a HRP conjugated complex will form. This enzyme reaction produces a color change, and the intensity of the absorbance at defined wave length indicates the presence or absence of the antigen or antibody in the sample. The test is specific, sensitive, reproducible and easy to operate.
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 Antibody Markers
BioChain provides antibodies which can be used for detecting protein expression in tissues, serum, or plasma with high specificity and sensitivity. Biomarker is an indicator of specific biological status. Some of the biomarkers in clinical use are single proteins, and most are serum-derived. Using antibodies to detect the expressions of those protein biomarkers are important for diagnosis, selection of therapy and prognosis.
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Antigen Markers
BioChain has various antigens as biomarkers that detect specific antibodies related to important diseases. Diseases such as viral infections and autoimmunity often result in the presence of antibodies against specific antigens in the patients' sera. These antibodies can be recognized by the matching antigens or fragments of the antigens in a sensitive immunoassay for diagnosis of the diseases.
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Lateral Flow Assay Kits
BioChain offers a series of lateral flow immunological assay kits. A lateral flow test works by incorporating a sample pad that is intimately associated with a conjugate pad. This in turn touches a membrane onto which test and control reagents have been immobilised. An absorbent pad wicks fluid away from the membrane. Using the lateral flow assay system, BioChain developed a series of kits that are useful for rapid diagnostic research of diseases.
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ELISA Kits
BioChain offers an extensive list of ELISA kits for research use of detection of infectious diseases, such as HBV, HCV, and HIV. The kits have also been approved for clinical diagnosis use in some countries such as China.
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Calcium Channel Cell Lines
Voltage-gated calcium channels control both electrical signal transduction and intracellular calcium level. They can be generally classified into three families, designated as CaV1~3 families. T-type Ca2+ channels, or low-voltage-activated calcium channels, belong to the CaV3 family ion channels. They are activated upon minute voltage changes near the resting membrane potential. Their activation has been shown to mediate cardiac action potential, neuronal rebound burst firing and synchronization of thalamic activity; their dysfunction has been associated with various neurological and cardiovascular disorders. Their interaction with potential antagonists and inhibitors has been associated with pharmacological treatments for pain and epilepsy. In the human genome, three genes encoding the T-channel pore subunits were identified as CaV3.1(alpha 1G), CaV3.2(alpha 1H), and CaV3.3(alpha 1I), each possessing unique biophysical kinetics in gating and firing properties. BioChain provides HEK-Cav3.x cells cryopreserved in quantity of 2X106 cells per vial.
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