Mesenchymal Stem Cells

Introduction to Mesenchymal Stem Cells

BioChain Mesenchymal Stem Cells (MSCs) are derived from bone marrow and selected by the attachment to culture vessels. MSCs are also called multipotent stromal cells. They are fibroblast-like Stem/progenitor cells residing in different tissues, including bone marrow and adipose tissue. Since MSCs can not only differentiate into different cell types (cartilage, muscle, endothelial and neural cells) but also secreting soluble factors to alter the tissue microenvironment, human MSCs have been used in clinical trials to treat various human diseases including: graft-versus-host disease (GVHD), cardiovascular diseases, neurological and inherited diseases. It is generally accepted that mouse bone marrow derived MSCs are CD44+, Sca1+, CD45-, c-Kit-, CD34- and CD31-.

Features

Primary cells

Progenitor cells

Capable of differentiating into into bone, cartilage, fat, muscle, tendon and marrow stroma

Applications

Mesenchymal Stem Cells (MSC) are capable of replication as undifferentiated cells.

Cell differentiation, including osteogenesis and bone mineralization, chondrogenesis and cartilage formation, adipogenesis and fat accumulation.

Gene delivery research

Functional genomics

Drug screening

High throughput screening and toxicology