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Mesenchymal Stem Cells
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Mesenchymal Stem Cells

Introduction to Mesenchymal Stem Cells

BioChain’s Mesenchymal Stem Cells (MSCs) are derived from bone marrow and are selected by their attachment to culture vessels. MSCs are also called multipotent stromal cells. They are fibroblast-like stem/progenitor cells residing in many different tissues, including bone marrow and adipose tissue. MSCs can differentiate into many different cell types (cartilage, muscle, endothelial and neural cells) and are also responsible for secreting soluble factors to alter the tissue microenvironment. Because of this, human MSCs have been used in clinical trials to treat various human diseases including: graft-versus-host disease (GVHD), cardiovascular diseases, neurological and inherited diseases. It is generally accepted that mouse bone marrow derived MSCs are CD44+, Sca1+, CD45-, c-Kit-, CD34- and CD31-.

Features

  • Primary cells
  • Progenitor cells
  • Capable of differentiating into into bone, cartilage, fat, muscle, tendon and marrow stroma
  • Applications

  • Mesenchymal Stem Cells (MSC) are capable of replication as undifferentiated cells.
  • Cell differentiation, including osteogenesis and bone mineralization, chondrogenesis and cartilage formation, adipogenesis and fat accumulation.
  • Gene delivery research
  • Functional genomics
  • Drug screening
  • High throughput screening and toxicology
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