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Endothelial Progenitor Outgrowth Cells
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Endothelial Progenitor Outgrowth Cells

Introduction to Endothelial Progenitor Outgrowth Cells

Endothelial Progenitor Outgrowth Cells (EPOC) play an important role in the process of both angiogenesis and vasculogenesis. Compared to specific mature types of endothelial cells such as HMVEC and HUVEC, EPOCs are more suitable for cell-based screening of anti-cancer drugs. In addition, EPOCs have impact on aging, suggesting potential uses of EPOCs in these areas. BioChain's EPOCs are a primitive cell type in the endothelial lineage. They are bone marrow derived cells with properties similar to those of embryonic angioblasts. These progenitor cells migrate into the blood stream and are able to differentiate into a variety of mature vascular endothelial cell types. EPOCs are adherent cells that are CD133 negative, CD34 positive, and CD146 positive. These cells are different from the earlier stage undifferentiated CD133 positive EPCs (#Z7030071).

Features

  • Primary cells
  • Better quality tube formation compared with endothelia cells, such as HUVEC and HMVEC
  • Progenitor outgrowth cells, not terminally differentiated mature endothelial cells such as HUVEC and HMVEC
  • Capable of differentiating into specific subtypes of endothelial cells such as vein endothelial cells, microvascular endothelial cells and aortic endothelial cells
  • Gene expression pattern is more similar to that of endothelial cells from tumors
  • Specifically migrate to tumors
  • Quantity and functions in the blood is altered during pathogenesis of a variety of diseases
  • Applications

  • Cancers such as lymphoma, breast cancer, lung cancer and inoperable heptocellular carcinoma (HCC)
  • Vascular diseases such as coronary artery disease (CAD) and acute myocardial infarction
  • Diabetes Mellitus
  • Ischemia
  • Pulmonary hypertension
  • Cerebral vascular disease
  • Arthritis
  • Cutaneous wound healing and skin regeneration
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