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Endothelial Progenitor
Outgrowth Cells
Features
¡ñ Primary cells
¡ñ Better quality tube formation compared with endothelia
cells, such as HUVEC and HMVEC
¡ñ Progenitor cells, not
terminally differentiated mature endothelial cells such as
HUVEC and HMVEC
¡ñ Capable of
differentiating into specific subtypes of endothelial cells,
change to CD 133- when attached to the cell culture vessel
¡ñ Gene expression pattern is more similar to that of
endothelial cells from tumors
¡ñ Specifically migrate to
tumors
¡ñ Quantity and
functions in the blood is altered during pathogenesis of a
variety of diseases
Applications
EPOC is a unique primitive
cell type and is involved in a variety of human diseases.
Isolated EPC outgrowth cells can be used in research and
drug discovery in the following areas:
¡ñ Cancers such as lymphoma, breast cancer, lung cancer and
inoperable heptocellular carcinoma (HCC)
¡ñ Vascular diseases such as coronary artery disease (CAD)
and acute myocardial infarction
¡ñ Diabetes Mellitus
¡ñ Ischemia
¡ñ Pulmonary hypertension
¡ñ Cerebral vascular disease
¡ñ Arthritis
¡ñ Cutaneous wound healing and skin regeneration
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